XBD has been re-branded as ENDOCANe

Click here fore ENDOCANe

​Cannabis-Free "CBD" Works Better than CBD

XBD has been Clinically Proven to:

  • Significantly Relieve Muscle & Joint Pain​​
  • Decrease Inflammation
  • Increase Muscle Strength
  • Enhance Joint Flexibility​​​ & Mobility

XBD Relieves Pain from the following:

  • Arthritis, Osteoporosis, Bursitis, RA
  • Body, Back and Joint Aches & Pain
  • Fibromyalgia, Plantar Fasciitis
  • Chronic Pain, Nerve Pain, Unresolved & Phantom Pain
  • Great for Muscle Pain and Recovery from Workout, Injury, or Surgery.
  • Works on Joint Pain caused by strains, sprains, bruising, or backaches.




Click item or toggle arrow for details:

Why is XBD Better than CBD?:

 XBD is made with Cannabinoids Naturally Produced by Your Own Body.        CBD & Hemp are Not Naturally Produced by Your Body.
Your Body Has its Own Cannabinoid system - called the Endo-Cannabinoid System ("ECS").
Every human has its own Endo-Cannabinoid System or "ECS" with receptors throughout our bodies. This system is involved in almost all brain and body functions, from our ability to handle pain, stress and anxiety to our mobility and muscle health. Our body utilizes the ECS to keep us healthy and balanced. The ECS helps to regulate sleep, immune-system response, pain & inflammation system response, relaxation, and more.

In performing its functions, our ECS naturally produces some cannabinoids called Endocannabinoids. The ECS consists of three main components: Endocannabinoids, Receptors, and Enzymes. 

Click here for more information on your body's EndoCannabinoid System.
Your Body Naturally Produces its Own Cannabinoids, (called EndoCannabinoids) one of which is called PEA for short.
PEA is short for Palmitoyethanolamide, an Endocannabinoid produced by our own bodies. PEA is produced locally in all our tissues in response to, and to help manage stress, pain and inflammation​. PEA does more than mask the pain, it actually works to remove its source. Summary points about PEA:
  • Is an endogenous or Endo-Cannabinoid (Comes from Inside Your own body)
  • Works on Receptors in your body’s ECS to soothe pain and inflammation.
  • Promotes Balance and Homeostasis of your ECS.
  • ​Has been shown to have anti-inflammatory, anti-nociceptive, neuroprotective, and anticonvulsant properties.
  • Has been called a Cannabimimetic, i.e. it mimics or has similar effects to those of cannabis.
  • Contributes to relaxation and restfulness leading to a better quality of sleep.
  • Declines with age, and is depleted by chronic conditions, resulting (without supplementation) in more pain and inflammation
  • Works through similar neural pathways as CBD, but unlike CBD, PEA has been affirmed GRAS (Generally Recognized as Safe)
  • Is Entirely Natural, Safe, Non-Habit Forming, Legal and Drug Test Compliant
XBD Pain Cream includes 24 grams (24000 mg) of the clinically studied and advanced form of PEA branded Levagen+ in each bottle.  There are 60 pumps of cream in each bottle, or approximately 400 mg of the Pain Relieving Cannabinoid PEA in each pump.  Compare that to topical CBD creams, which generally have 500 to 1000 mg of Cannabinoid in the entire bottle or container.

Click here for more information on PEA.
CBD is produced outside of your Body (called an ExoCannabinnoid) and Manufactured from Hemp and Cannabis.
Cannabinoids produced outside the body are called exo-Cannabinoids.  Those produced by plants are called phytocannabinoids.

CBD is short for cannabidiol, one of over 100 exo-cannabinoids produced by cannabis.  CBD is a non-psychoactive isomer of the more infamous tetrahydrocannabinol (THC), which means CBD has the same molecular formula as THC.

CBD, and other phytocannabinoids work by attempting to mimic the body's endocannabinoid system,  binding to ECS receptor sites throughout the brain and body.    CBD works not by direct effect, but by mimicking and attempting to inhibit the breakdown of your body's natural endocannabinoids.  

    
​
Technically, CBD isn’t providing any recognizable benefits on its own, it is our properly functioning endocannabinoid system that is providing many of the benefits that typically get attributed to CBD.   (Click for source of quote).
EndoCannabinoids are more Natural and Effective than ExoCannabinoies.
Our bodies recognize and respond more readily to substances that are produced naturally by it.  Substances that are produced, extracted, and manufactured outside of the body, such as CBD, are less likely to result in a consistent response from our bodies.  
​CBD does support the body's Endocannabinoid System by inhibiting the breakdown of your body's natural endocannabinoids.  But, if your body lacks endocannabinoids to begin with, (which is the case as we age, or our endocannabinoids are depleted by chronic pain) CBD has less effect.  There are better and safer ways to support a healthy Endocannabinoid System than CBD, ways that avoid the stigma and many severe risks of cannabis or hemp. ​Use of the natural EndoCannabinoid PEA is better, safer and less costly than CBD.
XBD Absorbs Better & Penetrates Deeper. ​  Hemp & CBD are Hydrophobic & Stay on Outer Skin Layers.
Our bodies more readily absorb substances that are produced naturally by it.  XBD Ingredients Absorb Better & Penetrate Deeper to Reach and Help Relieve the Source of your Pain.   

​Our Skin forms a barrier to substances that are produced, extracted, and manufactured outside of the body, such as Hemp and CBD.  Hemp and CBD are Hydrophobic substances, and tend to Stay on the Outer Layers of the Skin (see quote to the right and supporting link).
 "CBD is hydrophobic (meaning it isn’t water-soluble) and lipophilic (attracted to lipids, like oils) and tends to stay on the outer layer of skin or possibly accumulate in the sebaceous glands . . . Making a truly “water-soluble CBD” has been a challenge for the industry" (click for quote source)www.self.com/story/cbd-for-pain-topical
XBD has No Drug Test Risk.          CBD has Severe Drug Test Risks.
There are risks that CBD use may lead to a positive drug test result for THC.  This risk exists for a number of reasons, including the similarity in the chemical compounds between THC and CBD.  THC is a plant-based cannabinoid extracted from cannabis (Molecular Formula: C21H30O2).   CBD is also a plant-based cannabinoid extracted from cannabis and hemp (Molecular Formula: C21H30O2​).    CBD is an isomer of THC, which means CBD has the same molecular formula as THC.  There are concerns that in certain situations CBD may convert to THC, either prior to or after human use or consumption of CBD.  That is the case with both CBD Isolates as well as Full or Broad Spectrum CBD.
The current evidence indicates that gastric conversion of CBD to THC has been relatively consistently observed across multiple studies over the past half century; however, the circumstances in which this happens, and the subsequent clinical consequences, remain uncertain. (click for link to NIH article).
CBD Drug Test Risks are highlighted in the following categories
Click item or toggle arrow for details:
EMPLOYEE WORK RELATED DRUG TEST CBD RISKS
As an occupational medicine physician, I see a different side of CBD related to workplace drug testing.  CBD users are at high risk for having a test result report of "positive for marijuana." I see positive drug screen cases like this almost weekly in my drug test medical reviews.  (Letter to the Editor dated 2/23/2020 at this link)
School bus driver says she lost job after using legal CBD oil
WEST JORDAN — A Jordan School District bus driver said using over-the-counter CBD oil caused her to fail a drug test and lose her job.
Jeanette Hales failed the drug test despite using oil she said contains the legally permissible amount of less than 0.3% tetrahydrocannabinol, known as THC.
​Legal CBD Products Can Cause You To Fail A Drug Test
However, users beware. While CBD products contain less than .3 percent of THC, it will show up on a drug test.
“Everyone processes and stores cannabinoids differently," Mealor explained. . . .
While alternatives do exist, Mealor also has this advice. “We absolutely tell every one of our customers this: if you have a drug test, don’t chance it. You don’t know how you store it,” Mealor explained. 
Tennessee man says he was fired for testing positive for THC in CBD oils
NASHVILLE, Tenn. (WTVF) — A Tennessee man, who was fired after testing positive for THC, says he only used CBD oils – never marijuana. 
Hilton Mitchell started using CBD oils for his anxiety about a year ago. He says his other medications were taking a toll on him. CBD didn’t come with any side effects for Mitchell, and so he kept using it. 
CBD is legal in the State of Tennessee as long as the THC content is less than 0.3 percent. However, that can still show up on a drug test and Mitchell says it didn't stop him from being fired.
"I was pretty much astonish," said Hilton Mitchell. "I never thought I would fail a drug test."
CBD primarily comes from hemp and if you have hemp-derived CBD products that is perfectly legal in Tennessee but it doesn't necessarily mean you'll be in the clear for your drug test.
Weed? CBD? New products, new laws are causing confusion in the workplace
More than two dozen federal law enforcement employees, for example, have faced disciplinary action after testing positive for THC in the wake of using CBD products, says Don Mihalek, executive director of The Federal Law Enforcement Officers Association, a nonprofit professional association representing more than 26,000 federal officers. 
"There's no way to differentiate between THC in CBD oil and THC in marijuana,'' says Mihalek, who added that many officers have turned to CBD products as an alternative to pain medication. But with federal agencies having zero tolerance for positive drug test results "the agencies can’t afford to play a guessing game.''
U.S. Coast Guard: Using Hemp Products Can Lead to MMC Revocation
Airmen at Wyoming missile base relieved of security duties following alleged marijuana use
TRAVEL CBD RISKS

TSA STATEMENT ON TRAVELING WITH CANNABIS PRODUCTS, INCLUDING CBD

Marijuana and certain cannabis infused products, including some Cannabidiol (CBD) oil, remain illegal under federal law except for products that contain no more than 0.3 percent THC on a dry weight basis or that are approved by FDA. (See the Agriculture Improvement Act of 2018, Pub. L. 115-334.)  TSA officers are required to report any suspected violations of law to local, state or federal authorities. 
TSA’s screening procedures are focused on security and are designed to detect potential threats to aviation and passengers. Accordingly, TSA security officers do not search for marijuana or other illegal drugs, but if any illegal substance is discovered during security screening, TSA will refer the matter to a law enforcement officer.
For more prohibited items, please go to the 'What Can I Bring?' page.
The final decision rests with the TSA officer on whether an item is allowed through the checkpoint.
PROFESSIONAL LICENSING CBD RISK
​US COAST GUARD WARNING TO MARINERS ON CBD USE
FDA Statement on cbd use and driving
Taking Cannabidiol (CBD) Products and Driving Can Be Dangerous​there has been no FDA evaluation regarding whether unapproved CBD drug products are safe and effective to treat a particular disease or condition, what the proper dosage is, how they could interact with other drugs, foods or cosmetics, or whether they have dangerous side effects or other safety concerns. 
But we do know that CBD can cause sleepiness, sedation and lethargy, based on data from the approved prescription drug. Because of these side effects, consumers should use caution if planning on operating a motor vehicle after consuming any CBD products. 
We urge you to obtain more information about CBD by visiting: What You Need to Know About Products Containing Cannabis or Cannabis-derived Compounds, Including CBD.
FAA Federal Air surgeon Statement on CBD
example trucking company cdl cbd warning
An owner-operator/truck driver’s career may be on the line if a drug screen comes back positive.
It’s important to remember the following when it comes to CBD oil: The bottom line, any CBD or THC use is a violation waiting to happen.
DEPARTMENT OF TRANSPORTATION WARNINGS ON CBD RISK
  1. The labeling of many CBD products may be misleading because the products could contain higher levels of THC than what the product label states. . . 
  2. The Department of Transportation’s Drug and Alcohol Testing Regulation, Part 40, does not authorize the use of Schedule I drugs, including marijuana, for any reason.  Furthermore, CBD use is not a legitimate medical explanation for a laboratory-confirmed marijuana positive result. Therefore, Medical Review Officers will verify a drug test confirmed at the appropriate cutoffs as positive, even if an employee claims they only used a CBD product. . . 

    Since the use of CBD products could lead to a positive drug test result, Department of Transportation-regulated safety-sensitive employees should exercise caution when considering whether to use CBD products.
XBD has No Health Risk, is Affirmed GRAS (Safe).          CBD (and Hemp) have potential Severe Health Risks, Side Effects, and Adverse Events. ​
There are risks to your health that have been identified with CBD use. Both the US FDA and the UK FSA have released statements highlighting and summarizing the health risks of CBD use.  Excerpts from those statements are included below:
FDA Statement on health risks of cbd
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FDA statement on CBD. Click to read full statement
UK Fsa provides safety advice to consumers on cbd
FDA Expanded warning when pregnant and breastfeeding
Consumer REports Warning on CBD use
3. Watch for harmful drug interactions. Research suggests that CBD can undermine the effectiveness of some drugs and increase the risks of others, especially at high doses. “Highly concentrated CBD tinctures may interfere with the liver enzyme system that metabolizes a lot of pharmaceuticals,” Abrams says. That includes blood thinners such as warfarin (Coumadin and generic), antidepressants such as fluoxetine (Prozac and generic), and cholesterol-lowering statins such as atorvastatin (Lipitor and generic).
Also, cannabis plants contain other compounds (often referred to as cannabinoids) that could be in your CBD product. The most notable one, of course, is THC, which can alter your cognition and have long-term effects on learning and memory loss, according to the American Academy of Neurology.
Systematic Review Shows Serious Adverse Events from cannabis
"There was an increased risk of short-term AEs (Adverse Events) with cannabinoids, including serious AEs. Common AEs included dizziness, dry mouth, nausea, fatigue, somnolence, euphoria, vomiting, disorientation, drowsiness, confusion, loss of balance, and hallucination."pubmed.ncbi.nlm.nih.gov/26103030/
Hemp info from Verywellhealth, including side effects & Precautions
According to RX List, taking whole hemp by mouth can cause many side effects including:3

  • Throat irritation
  • Diarrhea
  • Nausea and vomiting
  • Bradycardia (slow heart rate)
  • Hypertension (high blood pressure)
There is not enough clinical research data to prove that hemp is safe for use in people who are pregnant or breastfeeding, or to use topically (on the skin).
www.verywellhealth.com/hemp-benefits-side-effects-dosage-and-interactions-4767355#:~:text=1%20Throat%20irritation%202%20Diarrhea%203%20Nausea%20and,(slow%20heart%20rate)%205%20Hypertension%20(high%20blood%20pressure)
There are ways to support a healthy Endocannabinoid System that avoid the stigma and risk of CBD, cannabis or hemp. ​​ XBD is 100% Natural, Safe, GRAS Affirmed (Generally Regarded As Safe) and Cannabis Free.
XBD is Proven by Hundreds of Human Clinical Trials.          CBD & Hemp Are Not Proven on Humans.
More than 500 clinical scientific research studies have shown that PEA (a key ingredient of XBD) is an effective and safe nutrient for reducing pain and inflammation, easing discomfort and aiding in a healthy inflammatory response.  This is real science proving real results on real people.  A large number of those studies have been on humans, like the ones below:
PictureXBD Ingredient Levagen+ Proven to Relieve Pain: Click for full Study Results
XBD Palmitoyethanolamide for Pain
XBD ingredient PEA Proven Effective in Human Clinical Trial Click for Details.
Click Here to see more information and more human clinical studies on PEA.
Studies exist that show that CBD reduces pain and inflammation.  But to date, those tests have been primarily on animals, not on humans.
XBD Costs Much Less.          CBD is 10 X More Costly.       
The price of CBD products varies greatly, from as little as $19 per 3 oz bottle to well over $100 per 2 or 3 oz bottle.  There are several factors that affect the price, but the key factor is the amount of CBD, or Cannabidiol that is included in each bottle or quantity of product.  The amount of CBD is expressed in milligrams (mg).  The key price comparison then is the price of the product per mg of Cannabidiol or Cannabinoid.  Included below is a link to a CBD price comparison calculator.
Price per mg of cannabinoid in XBD = $0.001 per mg     
Using the Price Comparison Calculator to calculate the price of XBD per mg of Cannabinoid (palmitoyethanolamide) included in XBD results in a price of $0.001 per mg.

Price comparison calculator
Price per mg of CBD topicals RANGES FROM $0.05 TO $0.15 PER MG
XBD Creates an "Entourage Effect" that Amplifies its Benefits.           CBD & Hemp alone Do Not.  
(XBD combined with CBD or Hemp creates an even greater "Entourage Effect" than either product used alone)
XBD Ingredients include the following:
  • ​PEA/Levagen+®: A Natural Pain Reliever and Non-Cannabis Cannabinoid that works in the same way, but better than CBD. (400 mg).
  • Vitamin D3: An Endo-Hormone that reduces the level of pain you experience. (5000 IU)
  • Celadrin®: A clinically proven anti-inflammatory and pain reliever.
  • Botanical Terpenes & Essential Oils: A Proprietary Blend of Essential Oils & Botanical Terpenes that are known to reduce pain & inflammation.
These ingredients have each been proven to fight pain and inflammation on their own.  Together they work synergistically through what is known as the "Entourage Effect” to Enhance and Amplify the pain relief and inflammation fighting benefits of each other.  The Entourage Effect magnifies the therapeutic benefits of the individual components—so that the therapeutic impact of the product is greater than the sum of its parts.  See more information about the ingredients, and the Entourage Effect in the XBD Details Ingredients section below.

XBD combined with CBD or Hemp creates an even greater "Entourage Effect" than either product used alone.
XBD has 10 X More Cannabinoid Potency. ​  CBD Pain Creams have only 10% as Much Potency.
XBD Pain Cream includes 24 grams (24000 mg) of the clinically studied and advanced form of PEA branded Levagen+ in each bottle.  There are 60 pumps of cream in each bottle, or approximately 400 mg of the Pain Relieving Cannabinoid PEA in each pump.  Compare that to topical CBD creams, which generally have 500 to 1000 mg of Cannabinoid in the entire bottle or container

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XBD Works for my wife's pains, up to this point it has helped more than anything else we tried. God Bless and thanks

George C.

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Works better than hemp.

Dallas G.

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nothing else I've used works but your cream does thank you!

Keith B.

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The Pain is Gone!!  I used XBD on the Plantar Fasciitis pain in my foot, and now after several weeks, the pain is gone.

Janet N.

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The XBD Pain cream has made a big improvement in my neuropathy Pain. I have tried so many things that haven’t worked, this is like a miracle to me. It’s amazing that it actually helps me, when you realize how much pain I have been in. God Bless You!

Rob A.

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loved your cream it actually helps end the pain in my legs!

Keith K.

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XBD PAIN CREAM INGREDIENTS & DETAILS:

Click item heading or toggle "+" to see details:
XBD Pain Cream Ingredients:
XBD ingredients work together to promote and support a healthy ECS, and then utilize the ECS to support the body’s natural anti-inflammatory response, support symptoms of mild to moderate arthritis, and promote flexibility, comfort and pain relief for your joints and muscles.
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Levagen+® is a clinically studied form of PEA that supports joint health and a healthy inflammatory response. Levagen utilizes the endocannabinoid system for supporting joint function, reducing joint stiffness and providing joint comfort. Levagen+® is an advanced form of PEA that includes LipiSperse® technology to increase functionality and bioavailability.
Levagen+® has been clinically proven to provide support for those with normal symptoms of mild to moderate osteoarthritis in the following ways:
  • supports joint function
  • reduces joint stiffness
  • provides joint comfort

Human clinical research on Levagen shows that it also works to help repair muscle tissue, minimize WOMAC pain scores and aid with sports-related inflammation, further strengthening its status as a Cannabidiol (CBD) substitute. Levagen is also self-affirmed GRAS, further substantiating its safety.
​
Click for more details and clinical research on Levagen.

Vitamin D3 is an endogenous hormone that our bodies make naturally in our skin from exposure to the sun's UVB rays. While best known for roles in maintaining bone health and the immune system, Vitamin D activates receptors that signal pain and inflammation reduction. Vitamin D receptors, like ECS receptors, are present in virtually every tissue and cell in your body, and adequate Vitamin D level is essential for optimal balance, homeostasis, and functioning of these tissues and cells. The vitamin D receptor is present in nerve cells called nociceptors, which sense pain. This means that vitamin D impacts the level or feeling of pain experienced.

​Click for more info and research on Vitamin D impact on pain.

Celadrin® is a clinically proven, effective and natural anti-inflammatory compound that safely promotes healthy joint function. It lubricates cell membranes throughout the body, restoring fluids that cushion bones and joints to promote flexibility and mobility.
​
Botanical Terpenes:

Terpenes are the naturally occurring aromatic and flavorful metabolites found in the oils of plants such as citrus, berries, mint, and pine. They are the main ingredient in essential oils. Terpenes do more than provide flavor and aroma. Studies are now confirming that terpenes have a multitude of mental and physical health benefits. One such specific benefit is that Terpenes have been shown to increase AMPK activation. AMPK is a protein kinase critically involved in the regulation of cellular energy homeostasis. Many studies have shown that AMPK activation exerts significant anti-inflammatory effects, as well as long-lasting reversal of pain hypersensitivity. Terpenes also enhance the absorption, penetration and permeation of other molecules through the skin, plus support those molecules in producing their beneficial physical and mental effects. Terpenes are found in, but are not unique to hemp and cannabis.

Our XBD Pain Cream includes a nourishing combination of botanically-derived terpenes, as well as other botanical and beneficial compounds. Key Botanical Terpenes include the following:

Menthol – An organic botanical terpene derived from peppermint herbs that have shown to promote relief from conditions related to pain, inflammation, congestion, and gastrointestinal issues.

Camphor – A botanical terpene from the wood of a camphor tree that relieves pain by increasing blood flow to the affected area. Camphor has demonstrated evidence in its ability to treat osteoarthritis, fungal infections, respiratory tract diseases, as well as heart disease symptoms.

Other Terpenes in our XBD Pain Cream include Aloe Vera, oil of nutmeg, oil of rosemary, and other botanicals. Terpenes included in these botanicals include limonene, pinene, camphene, beta-Caryophyllene, among others. These Terpenes were specially selected for support of supple joints, strong bones, relaxed muscles and resilient skin.

Terpenes and Synergistic "Entourage Effect"

​Terpenes and other botanicals interact synergistically to create what many people refer to as an “entourage effect” that magnifies the therapeutic benefits of the individual components—so that the therapeutic impact of the product is greater than the sum of its parts. This effect has been observed in treating neuropathic pain, headache, muscle spasm, spasticity, tremor and other movement disorders.
Topical ProductS WORK BETTER FOR PAIN:
When you take medications orally, a biological process called “first pass metabolism” breaks down and weakens chemical compounds before they have a chance to reach systemic circulation. With topical application, you bypass first pass metabolism. That means more of the product actually gets to its targeted tissues. Taking pills can also cause unwanted side effects for your kidneys, liver, heart and even brain.

XBD Pain Cream ingredients and advanced delivery methods enhance absorption and transport the active ingredients through the tissues penetrating deep into the supporting joints, muscles and tissues. Included ingredients induce change at a cellular level increasing skin permeability, which makes it easier for the other therapeutic ingredients to cross the dermal barrier. Once past the dermal barrier, these therapeutic compounds interact with your body’s ECS, activating cannabinoid receptors in joints, muscles and other soft tissue to alleviate inflammation, pain, and other body stressors. Ingredients reach the membranes of the joints to provide lubrication and support, reduce cartilage breakdown and provide relief to stiffened membranes caused by aging, general inflammation, or injury. During clinical trials, our solution was deeply absorbed at a rate of 95%.
xbd IS all natural, NON-GMO

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Our formula is made from natural and certified organic botanicals that are non-GMO and sustainably sourced, extracted through a natural process without the use of any harsh chemicals. We carefully formulated our XBD Pain Cream to be free of parabens, silicone, petroleum, plasticizers and other recognized harmful ingredients that you may find in other products in the market.
XBD CAN be used with CBD FOR EVEN BETTER results
XBD can also be used with CBD or Hemp for Enhanced Synergistic Effects (also called “Entourage Effects”) in promoting and supporting your Endocannabinoid System.  This may be useful in situations of intense or chronic pain.

The combination of XBD and Hemp or CBD creates a much more cost effective solution for pain than using CBD or Hemp alone.
xbd DIRECTIONS FOR USE:
Directions: Use 1 pump of the cream and apply it to the affected area(s), such as painful muscles or joints, as needed for pain relief. Continue to massage the cream until it is thoroughly absorbed into the skin. A slight discomfort and redness may temporarily occur. Since the formula contains natural ingredients that stimulate circulation, you may experience normal and temporary side effects such as slight discomfort or redness. Relief builds to full effect over several weeks. 
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The XBD Pain Cream comes in a metered pump making it easy to use daily and while you’re on the go.
Warnings: Avoid contact with eyes and mucous membranes. Do not apply to open wounds or damaged, irritated or broken skin. Keep out of the reach of children. For external use only. If irritation occurs discontinue use.