Clinical Studies Info Included below, or see Levagenplus website
How ENDOCANe Works to End Your Pain.
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> ENDOCANe is Infused with ENDOCANnabinoids Made by Your Own Body.
Hemp is Not Naturally Produced by Your Body.
Hemp is Not Naturally Produced by Your Body.
> Your Body Has its Own ENDOCANnabinoid System.
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Every human has its own Endogenous-Cannabinoid System or "ECS" with receptors throughout our bodies. This system is involved in almost all brain and body functions, from our ability to handle pain, stress and anxiety to our mobility and muscle health. Our body utilizes the ECS to keep us healthy and balanced. The ECS helps to regulate sleep, immune-system response, pain & inflammation system response, relaxation, and more.
In performing its functions, our Endogenous Cannabinoid System naturally produces cannabinoids, which are called Endocannabinoids. The ECS consists of three main components: Endocannabinoids, Receptors, and Enzymes. Click here for more information on your body's EndoCannabinoid System. |
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> Your Body Produces its Own Natural ENDOCANnabinoids
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PEA is short for Palmitoylethanolamide, an Endocannabinoid produced by our own bodies. PEA is both an anti-inflammatory and an analgesic (pain killer) working through the same pathways as Hemp. PEA is produced locally in all our tissues in response to, and to help manage stress, pain and inflammation. The role of PEA in our body is to help the body's tissues heal faster, remove the source of pain and reduce inflammation. As you can see, PEA does so much more than simply mask the pain, which is all that many pain relief products can do.
In conditions such as fibromyalgia, rheumatoid arthritis and osteoarthritis, the body has fallen out of balance where autoimmunity and auto-inflammation has taken over the body, leading to chronic pain and widespread inflammation. Those people suffering such conditions can begin experiencing great improvement with PEA treatment bringing the inflammation back under control. After PEA has gone to work on treating the source of problems in the body, it breaks down into the Endocannabinoid anandamide (AEA). AEA has been called the "Bliss Molecule" , a compound present in mothers breast milk, which supports healthy human functioning. PEA helps boost production and retention of AEA so that your body can respond to pain and inflammation more effectively. |
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Summary points about PEA:
More Information on PEA Benefits & Clinical Studies is available here.
- Is an Endogenous or Endo-Cannabinoid ("Endo" means it comes from Inside Your own body)
- Works on Receptors in your body’s EndoCannabinoid system, or ECS, to soothe pain and inflammation.
- Promotes Balance and Homeostasis of your ECS.
- Has been shown to have anti-inflammatory, anti-nociceptive, neuroprotective, and anticonvulsant properties.
- Boosts production and retention of Anandamide, the “Bliss Molecule”
- Contributes to relaxation and restfulness leading to a better quality of sleep.
- Declines with age, and is depleted by chronic conditions, resulting (without supplementation) in more pain and inflammation
- Works through similar neural pathways as Hemp, but unlike Hemp, PEA has been affirmed GRAS (Generally Recognized as Safe)
- Is Entirely Natural, Safe, Non-Habit Forming, Legal and Drug Test Compliant
More Information on PEA Benefits & Clinical Studies is available here.
ENDOCANe Pain Relief Cream includes 12,000 mg of PEA in each bottle. There are 60 pumps of pain relief cream in each bottle, or approximately 200 mg of the Pain Relieving EndoCannabinoid PEA in each pump.
> Hemp Ingredients are Manufactured from the Hemp plant.
Hemp is not produced by your body, nor is it a natural part of Your Endocannabinoid System, nor necessary for its proper functioning. Hemp can have an effect on your Endocannabinoid System by inhibiting the breakdown of your body's naturally produced Endocannabinoids.
> ENDOCANnabinoids are more Effective than Hemp.
Hemp does support the body's Endocannabinoid System by inhibiting the breakdown of your body's natural Endocannabinoids. But, if your body lacks Endocannabinoids to begin with, (which is the case as we age, or our Endocannabinoids are depleted by injury or chronic pain) Hemp has less effect.
Our bodies recognize and respond more readily to substances that are produced naturally by it. Substances that are produced, extracted, and manufactured outside of the body, such as Hemp, are less likely to result in a consistent response from our bodies.
Using substances naturally produced by your body, such as PEA, is a better and safer way to support Your Endocannabinoid System, and avoids any inconsistencies or unpredictability of Hemp.
Our bodies recognize and respond more readily to substances that are produced naturally by it. Substances that are produced, extracted, and manufactured outside of the body, such as Hemp, are less likely to result in a consistent response from our bodies.
Using substances naturally produced by your body, such as PEA, is a better and safer way to support Your Endocannabinoid System, and avoids any inconsistencies or unpredictability of Hemp.
> ENDOCANe Absorbs Better & Penetrates Deeper.
Hemp is Hydrophobic & Stays on Skin Outer Layers.
Hemp is Hydrophobic & Stays on Skin Outer Layers.
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ENDOCANe Ingredients are formulated with Botanical Terpenes that promote absorption and greater bioavailability. In addition, our bodies more readily absorb substances that are produced naturally by it. Because of this, ENDOCANe Absorbs Better & Penetrates Deeper to Reach and Help Relieve the Source of your Pain.
Our Skin forms a barrier to substances that are produced, extracted, and manufactured outside of the body, such as Hemp. Hemp is a Hydrophobic substance, and tends to Stay on the Outer Layers of the Skin (see quote to the right and supporting link). |
"Hemp Oil tends to stay on the outer layer of skin or possibly accumulate in the sebaceous glands . . . Hemp and cannabinoids are lipophilic (faty) compounds that are water insoluble and thereby do not disperse well in water-based formulations. Consequently, this results in poor biological absorption and bioavailability. source)www.psc-grp.com/water-soluble/ |
> ENDOCANe Has No Drug Test Risk.
Hemp Poses Potential Drug Test Risks.
Hemp Poses Potential Drug Test Risks.
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ENDOCANe is 100% Cannabis-Free, and therefore has Zero risk of a positive drug test. In addition, the Endocannabinoid ingredient Levagen+ has been tested and received Informed Ingredient Certification (see right) Informed Ingredient certification provides assurance an ingredient has been manufactured to high-quality standards. All ingredients certified by Informed Ingredient are robustly tested for substances banned in sport using ISO 17025 accredited methods. This accreditation is the standard for the sports nutrition industry.
There are risks that Hemp use may lead to a positive drug test result for THC. Granted the risks are small, but they do exist according to the article referenced below:
Answer: It is possible to fail a drug test for ("marijuana based on THC") in a hemp oil, hemp seed, or hemp seed extract -- |
Click for link to Informed Ingredient Certification of Levagen+
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> ENDOCANe is Affirmed GRAS (Generally Regarded As Safe).
Hemp Poses Potential Side Effects and Health Risks.
Hemp Poses Potential Side Effects and Health Risks.
One of the biggest benefits of PEA is that to date, it currently has no known side effects in either short or long term use (including no overdose level found). Researchers haven’t found any tolerance build up when used long-term; and no allergic reactions. Another interesting discovery about PEA, is that it doesn’t have any contraindications with other medications commonly prescribed for the same conditions PEA can assist with. Those same debilitating conditions (such as chronic pain), when treated with more conventional medications, come with a long list of side effects. This is why PEA can be a breakthrough for people suffering from chronic pain conditions and/or inflammation.
There are potential side effects and risks to your health that have been identified with Hemp use. The body's physical response to Hemp use is notably inconsistent and unpredictable, both from person to person, and use to use, making dosage determinations extremely difficult.
HEMP INFO FROM VERYWELLHEALTH, INCLUDING SIDE EFFECTS & PRECAUTIONS
According to RX List, taking whole hemp by mouth can cause many side effects including:3There is not enough clinical research data to prove that hemp is safe for use in people who are pregnant or breastfeeding, or to use topically (on the skin).
- Throat irritation
- Diarrhea
- Nausea and vomiting
- Bradycardia (slow heart rate)
- Hypertension (high blood pressure)
www.verywellhealth.com/hemp-benefits-side-effects-dosage-and-interactions-4767355#:~:text=1%20Throat%20irritation%202%20Diarrhea%203%20Nausea%20and,(slow%20heart%20rate)%205%20Hypertension%20(high%20blood%20pressure)
WEBMD: INFORMATION ON HEMP
Dosing: The appropriate dose of hemp depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hemp. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
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There are ways to support a healthy Endocannabinoid System that avoid the inconsistencies and potential risks of Hemp.
ENDOCANe is 100% Natural, Safe, GRAS Affirmed (Generally Regarded As Safe) and Cannabis-Free. |
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> ENDOCANe Benefits are Clinically Proven by Hundreds of Human Clinical Trials.
Hemp Pain Effects Are Not Clinically Proven on Humans.
Hemp Pain Effects Are Not Clinically Proven on Humans.
More than 500 clinical scientific research studies have shown that PEA (a key ingredient of ENDOCANe) is an effective and safe nutrient for reducing pain and inflammation, easing discomfort and aiding in a healthy inflammatory response. This is real science proving real results on real people. A large number of those studies have been on humans, like the ones below:
STUDIES ON HEMP
Studies have been done on how Hemp related compounds affect pain and inflammation. But to date, those tests have been primarily on animals, not on humans.
"There's a lot of studies that have been done in animals and those tend to show that it's anti-inflammatory and that it does have some analgesic effect," says Boehnke. "Unfortunately they haven't been well translated in humans."
Click for link to full article.
> ENDOCANe Promotes an "Entourage Effect" that Amplifies its Benefits.
Hemp Isolate and Hemp seed oil alone Do Not.
Hemp Isolate and Hemp seed oil alone Do Not.
ENDOCANe is specially formulated with the following Ingredients:
- EndoCannabinoid PEA Palmitoylethanolamide: A Clinically Proven Natural Pain Reliever and EndoCannabinoid that works similar to, but better than Hemp. (200 mg).
- Botanical Terpenes: A Proprietary Blend of Botanical Terpenes, including Beta-Caryophellene, that have been clinically proven to interact with the body's EndoCannabinoid System to reduce pain & inflammation.
- D3 Sunshine Vitamin: An Endo-Hormone that reduces the level of pain you experience. (2000 IU)
These ingredients have been proven to fight pain and inflammation on their own. Together they work synergistically through what is known as the "Entourage Effect” to Enhance and Amplify the pain relief and inflammation fighting benefits of each other. The Entourage Effect magnifies the therapeutic benefits of the individual components—so that the therapeutic impact of the product is greater than the sum of its parts. See more information about the ingredients, and the Entourage Effect in the ENDOCANe Details Ingredients section below.
> ENDOCANe is Hemp Synergistic - Can be Used Together for Greater "Entourage Effect"
ENDOCANe combined with Hemp creates an even Greater "Entourage Effect" than either used alone.
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I have had chronic back pain ever since I was in a car accident in 2014. Nothing I tried provided relief from the pain, until I tried Endocane Pain Cream. I have felt significant improvement in the level of pain since starting applying the cream, and am now sleeping through the night.
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ENDOCANe Ingredients & Other Details:
Click ">" Bulleted Titles to expand or collapse details:
> ENDOCANe Pain Cream Ingredients
ENDOCANe is infused with:
PEA that supports joint health and a healthy endogenous inflammatory response. PEA utilizes the endocannabinoid system for supporting joint function, reducing joint stiffness and providing joint comfort.
- ENDOCANnabinoids (Levagen+ PEA)
- Botanical Terpenes
- D3 Sunshine Vitamins
PEA that supports joint health and a healthy endogenous inflammatory response. PEA utilizes the endocannabinoid system for supporting joint function, reducing joint stiffness and providing joint comfort.
PEA has been clinically proven to provide support for those with normal symptoms of mild to moderate osteoarthritis in the following ways:
Human clinical research on PEA shows that it also works to help repair muscle tissue, minimize WOMAC pain scores and aid with sports-related inflammation, further strengthening its status as a Hemp substitute.
- supports joint function
- reduces joint stiffness
- provides joint comfort
Human clinical research on PEA shows that it also works to help repair muscle tissue, minimize WOMAC pain scores and aid with sports-related inflammation, further strengthening its status as a Hemp substitute.
Videos on ENDOCANe Ingredient PEA
Botanical Terpenes:
Terpenes are the naturally occurring aromatic and flavorful metabolites found in the oils of plants such as citrus, berries, mint, and pine. They are the main ingredient in essential oils. Terpenes do more than provide flavor and aroma. Studies are now confirming that terpenes have a multitude of mental and physical health benefits.
One such specific benefit is that Terpenes have been shown to increase AMPK activation. AMPK is a protein kinase critically involved in the regulation of cellular energy homeostasis. Many studies have shown that AMPK activation exerts significant anti-inflammatory effects, as well as long-lasting reversal of pain hypersensitivity. Terpenes also enhance the absorption, penetration and permeation of other molecules through the skin, plus support those molecules in producing their beneficial physical and mental effects. Terpenes are found in, but are not unique to hemp.
Our ENDOCANe Pain Cream includes a nourishing combination of botanically-derived terpenes, as well as other botanical and beneficial compounds. Key Botanical Terpenes include the following:
Beta-Caryophellene -Beta-Caryophyllene (BCP) stands out as a unique terpene because it is one of the first non-cannabinoids known to directly activate cannabinoid receptors. Clinical evidence has shown that BCP interacts with the body's Endocannabinoid System, offering relief from pain and inflammation.
Click for more info and research on Beta-Caryophyllene
Article on Beta-Caryophyllene
Menthol – An organic botanical terpene derived from peppermint herbs that have shown to promote relief from conditions related to pain, inflammation, congestion, and gastrointestinal issues.
Camphor – A botanical terpene from the wood of a camphor tree that relieves pain by increasing blood flow to the affected area. Camphor has demonstrated evidence in its ability to treat osteoarthritis, fungal infections, respiratory tract diseases, as well as heart disease symptoms.
Cetyl Myristoleate is a clinically proven, effective and natural anti-inflammatory compound that safely promotes healthy joint function. It lubricates cell membranes throughout the body, restoring fluids that cushion bones and joints to promote flexibility and mobility.
Other Terpenes in our ENDOCANe Pain Cream include Sweet Birch Oil, Eucalyptus Oil, Boswellia, Peppermint Oil and other botanicals. Terpenes included in these botanicals include limonene, pinene, camphene, among others. These Terpenes were specially selected for support of supple joints, strong bones, relaxed muscles and resilient skin, as well as to promote absorption and greater bioavailability of ingredients.
Vitamin D3 is an Endogenous hormone that our bodies make naturally in our skin from exposure to the sun's UVB rays. While best known for roles in maintaining bone health and the immune system, Vitamin D activates receptors that signal pain and inflammation reduction. Vitamin D receptors, like ECS receptors, are present in virtually every tissue and cell in your body, and adequate Vitamin D level is essential for optimal balance, homeostasis, and functioning of these tissues and cells. The vitamin D receptor is present in nerve cells called nociceptors, which sense pain. This means that vitamin D impacts the level or feeling of pain experienced.
Click for more info and research on Vitamin D impact on pain.
Synergistic "Entourage Effect"
Botanical Terpenes, as well as the Essential Oils and Vitamins, interact synergistically to create what many people refer to as an “entourage effect” that magnifies the therapeutic benefits of the individual components— so that the therapeutic impact of the product is greater than the sum of its parts. This effect has been observed in treating neuropathic pain, headache, muscle spasm, spasticity, tremor and other movement disorders.
Terpenes are the naturally occurring aromatic and flavorful metabolites found in the oils of plants such as citrus, berries, mint, and pine. They are the main ingredient in essential oils. Terpenes do more than provide flavor and aroma. Studies are now confirming that terpenes have a multitude of mental and physical health benefits.
One such specific benefit is that Terpenes have been shown to increase AMPK activation. AMPK is a protein kinase critically involved in the regulation of cellular energy homeostasis. Many studies have shown that AMPK activation exerts significant anti-inflammatory effects, as well as long-lasting reversal of pain hypersensitivity. Terpenes also enhance the absorption, penetration and permeation of other molecules through the skin, plus support those molecules in producing their beneficial physical and mental effects. Terpenes are found in, but are not unique to hemp.
Our ENDOCANe Pain Cream includes a nourishing combination of botanically-derived terpenes, as well as other botanical and beneficial compounds. Key Botanical Terpenes include the following:
Beta-Caryophellene -Beta-Caryophyllene (BCP) stands out as a unique terpene because it is one of the first non-cannabinoids known to directly activate cannabinoid receptors. Clinical evidence has shown that BCP interacts with the body's Endocannabinoid System, offering relief from pain and inflammation.
Click for more info and research on Beta-Caryophyllene
Article on Beta-Caryophyllene
Menthol – An organic botanical terpene derived from peppermint herbs that have shown to promote relief from conditions related to pain, inflammation, congestion, and gastrointestinal issues.
Camphor – A botanical terpene from the wood of a camphor tree that relieves pain by increasing blood flow to the affected area. Camphor has demonstrated evidence in its ability to treat osteoarthritis, fungal infections, respiratory tract diseases, as well as heart disease symptoms.
Cetyl Myristoleate is a clinically proven, effective and natural anti-inflammatory compound that safely promotes healthy joint function. It lubricates cell membranes throughout the body, restoring fluids that cushion bones and joints to promote flexibility and mobility.
Other Terpenes in our ENDOCANe Pain Cream include Sweet Birch Oil, Eucalyptus Oil, Boswellia, Peppermint Oil and other botanicals. Terpenes included in these botanicals include limonene, pinene, camphene, among others. These Terpenes were specially selected for support of supple joints, strong bones, relaxed muscles and resilient skin, as well as to promote absorption and greater bioavailability of ingredients.
Vitamin D3 is an Endogenous hormone that our bodies make naturally in our skin from exposure to the sun's UVB rays. While best known for roles in maintaining bone health and the immune system, Vitamin D activates receptors that signal pain and inflammation reduction. Vitamin D receptors, like ECS receptors, are present in virtually every tissue and cell in your body, and adequate Vitamin D level is essential for optimal balance, homeostasis, and functioning of these tissues and cells. The vitamin D receptor is present in nerve cells called nociceptors, which sense pain. This means that vitamin D impacts the level or feeling of pain experienced.
Click for more info and research on Vitamin D impact on pain.
Synergistic "Entourage Effect"
Botanical Terpenes, as well as the Essential Oils and Vitamins, interact synergistically to create what many people refer to as an “entourage effect” that magnifies the therapeutic benefits of the individual components— so that the therapeutic impact of the product is greater than the sum of its parts. This effect has been observed in treating neuropathic pain, headache, muscle spasm, spasticity, tremor and other movement disorders.
> ENDOCANe Works Better for Targeted Pain Relief
ENDOCANe lets you target a specific area of your body, such as the joints, for relief of pain and inflammation.
When you take medications orally, a biological process called “first pass metabolism” breaks down and weakens chemical compounds before they have a chance to reach systemic circulation. With topical application, you bypass first pass metabolism. That means more of a topical product's beneficial ingredients actually gets to the targeted joints and tissues. Oral pills don’t work in a laser targeted fashion. Their effects tend to be more global throughout the entire body, and are therefore more likely to also cause unwanted "off-target" side effects for your kidneys, liver, heart and even brain.
ENDOCANe Pain Cream incorporates select ingredients that promote absorption and greater bioavailability to transport the active ingredients through skin and tissue layers, penetrating deep into the supporting joints, muscles and targeted tissues. Specially formulated ingredients induce change at a cellular level increasing skin permeability, which makes it easier for the other therapeutic ingredients to cross the dermal barrier. Once past the dermal barrier, these therapeutic compounds interact with your body’s ECS, activating endocannabinoid receptors in joints, muscles and other soft tissue to alleviate inflammation, pain, and other body stressors. ENDOCANe ingredients reach the membranes of the targeted joints to provide lubrication and support, reduce cartilage breakdown and provide relief to stiffened membranes caused by aging, general inflammation, or injury.
When you take medications orally, a biological process called “first pass metabolism” breaks down and weakens chemical compounds before they have a chance to reach systemic circulation. With topical application, you bypass first pass metabolism. That means more of a topical product's beneficial ingredients actually gets to the targeted joints and tissues. Oral pills don’t work in a laser targeted fashion. Their effects tend to be more global throughout the entire body, and are therefore more likely to also cause unwanted "off-target" side effects for your kidneys, liver, heart and even brain.
ENDOCANe Pain Cream incorporates select ingredients that promote absorption and greater bioavailability to transport the active ingredients through skin and tissue layers, penetrating deep into the supporting joints, muscles and targeted tissues. Specially formulated ingredients induce change at a cellular level increasing skin permeability, which makes it easier for the other therapeutic ingredients to cross the dermal barrier. Once past the dermal barrier, these therapeutic compounds interact with your body’s ECS, activating endocannabinoid receptors in joints, muscles and other soft tissue to alleviate inflammation, pain, and other body stressors. ENDOCANe ingredients reach the membranes of the targeted joints to provide lubrication and support, reduce cartilage breakdown and provide relief to stiffened membranes caused by aging, general inflammation, or injury.
> ENDOCANe is All Natural, Non-GMO
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ENDOCANe is formulated and infused with all natural and certified organic botanicals that are non-GMO and sustainably sourced, extracted through a natural process without the use of any harsh chemicals. We carefully formulated our ENDOCANe Pain Cream to be free of parabens, silicone, petroleum, plasticizers and other recognized harmful ingredients that you may find in other products in the market.
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> ENDOCANe Works Synergistically with Hemp for Greater Effects:
ENDOCANe can also be used with Hemp for Enhanced Synergistic Effects (also called “Entourage Effects”) in promoting and supporting your Endocannabinoid System. This may be useful in situations of intense or chronic pain.
> ENDOCANe Directions for Use:
Directions: Use 1 pump of the cream and apply it to the affected area(s), such as painful muscles or joints, as needed for pain relief. Continue to massage the cream until it is thoroughly absorbed into the skin. Since the formula contains natural ingredients that stimulate circulation, you may experience normal and temporary side effects such as slight tingling or redness. Pain Relief builds to full effect over time, generally over a several week period.
ENDOCANe Pain Cream comes in a metered pump making it easy to use daily and while you’re on the go.
ENDOCANe Pain Cream comes in a metered pump making it easy to use daily and while you’re on the go.
Warnings: Avoid contact with eyes and mucous membranes. Do not apply to open wounds or damaged, irritated or broken skin. Keep out of the reach of children. For external use only. If irritation occurs (which is rare) discontinue use.
