What is PEA (palmitoylethanolamide)?
- Natural fatty acid amide produced by our own bodies (“Endocannabinoid Family”’)
- Produced locally in all our tissues in response to stress, pain and inflammation
- Works on pathways of body’s Endocannabinoid System (ECS) similar to CBD.
- Enhances synergistic Entourage effect of CBD and other Endo- and Phyto- Cannabinoids.
- Supports symptoms of mild to moderate osteoarthritis
- Supports joint function
- Reduces joint stiffness
- Provides joint comfort
Palmitoylethanolamide (PEA), is an endogenous fatty acid amide. PEA is produced naturally by the body on demand as a biological response and accumulates and is used locally in all tissues. PEA is a first responder repair and restore mechanism to pain, stress, and inflammation. The antiinflammatory and antihyperalgesic activity of PEA suggests that this molecule is an endogenous regulator of nociception and inflammation. Probably due to the fact that PEA is an endogenous modulator as well as a compound in food, such as eggs and milk, no serious side effects have been reported, nor have drug–drug interactions.
PEA is structurally related to the endogenous cannabinoid transmitter, anandamide (AEA). AEA is associated with regulating pain and the more AEA in the bloodstream, the less discomfort a person may feel. PEA has numerous clinical studies demonstrating its potential as an effective and safe anti-inflammatory, analgesic and tissue-protective nutrient. PEA utilizes the endocannabinoid system, working its actions at CB1, CB2, and GPR55 receptors, and TRPV1 channels for supporting joint function, reducing joint stiffness and providing joint comfort. PEA can also contribute to relaxation and restfulness leading to a better quality of sleep.
Topical PEA is ideal for local application to an affected area of skin, muscle, or joints. PEA applied topically tends to stay concentrated in the area where it was applied. Clinical studies are confirming its therapeutic benefit in combatting pain and inflammation, as well as general well being.
A number of researchers have shown in recent years that the endocannabinoid system plays a role in providing substantial relief for objective and subjective symptoms of skin diseases, including atopic eczema, facial postherpetic neuralgia, and contact allergic dermatitis. It has also been documented that the endocannabinoid system has the ability to prevent skin damage as a result of exposure to ultraviolet rays. Its main physiological function is to constitutively control and balance the proliferation, differentiation, and survival of skin cells.
See links and quotes below for further information:
PEA is structurally related to the endogenous cannabinoid transmitter, anandamide (AEA). AEA is associated with regulating pain and the more AEA in the bloodstream, the less discomfort a person may feel. PEA has numerous clinical studies demonstrating its potential as an effective and safe anti-inflammatory, analgesic and tissue-protective nutrient. PEA utilizes the endocannabinoid system, working its actions at CB1, CB2, and GPR55 receptors, and TRPV1 channels for supporting joint function, reducing joint stiffness and providing joint comfort. PEA can also contribute to relaxation and restfulness leading to a better quality of sleep.
Topical PEA is ideal for local application to an affected area of skin, muscle, or joints. PEA applied topically tends to stay concentrated in the area where it was applied. Clinical studies are confirming its therapeutic benefit in combatting pain and inflammation, as well as general well being.
A number of researchers have shown in recent years that the endocannabinoid system plays a role in providing substantial relief for objective and subjective symptoms of skin diseases, including atopic eczema, facial postherpetic neuralgia, and contact allergic dermatitis. It has also been documented that the endocannabinoid system has the ability to prevent skin damage as a result of exposure to ultraviolet rays. Its main physiological function is to constitutively control and balance the proliferation, differentiation, and survival of skin cells.
See links and quotes below for further information:
Your skin is a self-regulating organ designed by nature, like the ECS, to help your body maintain balance and homeostasis. Its functions include to protect, prevent, maintain, heal, recover and improve your mental and physical health. In performing these roles, your skin both makes and absorbs natural elements that are both helpful and critical to its structure and function, and to your overall health, while working to reject and excrete toxins and unhealthful substances.
Your skin works in conjunction with your body to adapt to its environment and self-regulate both creation and absorption of nutrients, vitamins and minerals based on your body's needs and existing levels. Your digestive system is less reliable and can cause inconsistencies with absorption of pills and other oral forms, dependent on factors such as the type and quantity of food in the digestive system, time of day, etc. Topical application and transdermal absorption is naturally better suited to control and balance Cannabinoid levels in relation to your body's fluctuating needs, in balance with other hormones, vitamins and minerals.
Your skin works in conjunction with your body to adapt to its environment and self-regulate both creation and absorption of nutrients, vitamins and minerals based on your body's needs and existing levels. Your digestive system is less reliable and can cause inconsistencies with absorption of pills and other oral forms, dependent on factors such as the type and quantity of food in the digestive system, time of day, etc. Topical application and transdermal absorption is naturally better suited to control and balance Cannabinoid levels in relation to your body's fluctuating needs, in balance with other hormones, vitamins and minerals.
RESEARCH ARTICLES, WITH SELECT QUOTES
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PEA has demonstrated effectiveness for chronic pain of multiple types associated with many painful conditions, especially with neuropathic (nerve) pain, inflammatory pain and visceral pain such as endometriosis and interstitial cystitis.
how PEA works in the body. “It’s an endogenous fatty acid amide produced by the body in response to stressors, pain, and inflammation,” he said. “So it acts as a very good pain reliever for multiple types of pain and inflammation. It’s the body’s own anti-inflammatory and pain-control mechanism as a first responder.”
Not only that, he said, but it is produced throughout the body. “The uniqueness of PEA is that it’s an autacoid,” he said. “Autacoids are produced and used up locally in every tissue; it’s not just produced in one particular organ.” As a result, it’s produced where there is inflammation and pain in the body, he said.
He added that the ingredient is fast-acting (starts working within 15 minutes), and that its half-life is eight hours in the body; however, PEA’s effects are even longer lasting than that, he said. “It prevents the output of inflammatory cytokines and interleukins into your system, and because of this, the effects last longer because it acts on the cause, not on the symptoms,” he explained. “The half-life is eight hours in the body, but the effect you get happens throughout the day because it shuts off the source of the inflammation and the source of the pain.”
PEA, currently marketed as medical food against neuropathic pain(Petrosino and Di Marzo, 2017), counteracts pain and modifies several of the biochemical and functional changes induced by vitamin D deficiency
Results: The results showed that, although some aspects were improved in both groups, the group using the emollient containing PEA/AEA presented a better skin surface change in capacitance. However, the most impressive finding was the ability of the PEA/AEA emollient to increase the 5 Hz current perception threshold to a normal level after 7 days, with a significant difference between values at baseline and after 14 days. A current perception threshold of 5 Hz was positively and significantly correlated with skin surface hydration and negatively correlated with transepidermal water loss in the PEA/AEA emollient group.
Conclusion: Compared with traditional emollients, regular application of a topical PEA/AEA emollient could improve both passive and active skin functions simultaneously.
Palmitoylethanolamide (PEA) is an endogenous fatty acid amide that, through modulation of mast cells and spinal glial cells activation on peripheral and central nervous system neurons, has been demonstrated to be effective on the different inflammatory mechanisms that develop and maintain both neurogenic and neuropathic pain
PEA . . . performs a great variety of biological functions related to chronic and neuropathic pain and inflammation, as has been demonstrated in clinical trials. These include peripheral neuropathies such as diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome, sciatic pain, osteoarthritis, low-back pain, failed back surgery syndrome, dental pains, neuropathic pain in stroke and multiple sclerosis, chronic pelvic pain, postherpetic neuralgia, and vaginal pains.
Conclusions: This observational study provides evidence, albeit preliminary, for the efficacy and safety of um-PEA (Normast) as part of a multimodal therapeutic regimen in the treatment of pain-resistant patients
In summary, available data from rodent and human studies support the safety of PEA in general, and of microPEA specifically, in products intended for human and companion animal consumption.
